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Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity
Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease. It also accumulates in Niemann-Pick disease types A and B with primary storage of SM and with cholesterol in type C. Reconstitution of GM2 catabolism with β-hexosaminidase A and GM2 activator protein (GM2AP) at uncharged l...
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| Udgivet i: | J Lipid Res |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Biochemistry and Molecular Biology
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4548779/ https://ncbi.nlm.nih.gov/pubmed/26175473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M061036 |
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