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Membrane lipids regulate ganglioside GM2 catabolism and GM2 activator protein activity

Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease. It also accumulates in Niemann-Pick disease types A and B with primary storage of SM and with cholesterol in type C. Reconstitution of GM2 catabolism with β-hexosaminidase A and GM2 activator protein (GM2AP) at uncharged l...

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Bibliografski detalji
Izdano u:J Lipid Res
Glavni autori: Anheuser, Susi, Breiden, Bernadette, Schwarzmann, Günter, Sandhoff, Konrad
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4548779/
https://ncbi.nlm.nih.gov/pubmed/26175473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M061036
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