Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion

We examined the effect of Niemann-Pick disease type 2 (NPC2) protein and some late endosomal lipids [sphingomyelin, ceramide and bis(monoacylglycero)phosphate (BMP)] on cholesterol transfer and membrane fusion. Of all lipid-binding proteins tested, only NPC2 transferred cholesterol at a substantial...

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Main Authors: Abdul-Hammed, Misbaudeen, Breiden, Bernadette, Adebayo, Matthew A., Babalola, Jonathan O., Schwarzmann, Günter, Sandhoff, Konrad
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Biochemistry and Molecular Biology 2010
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2882726/
https://ncbi.nlm.nih.gov/pubmed/20179319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M003822
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