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An unaltered orthosteric site and a network of long-range allosteric interactions for PNU-120596 in α7 nicotinic acetylcholine receptors

Nicotinic acetylcholine receptors (nAChRs) are vital to neuronal signaling, are implicated in important processes such as learning and memory, and are therapeutic targets for neural diseases. The α7 nAChR has been implicated in Alzheimer’s disease and schizophrenia, and allosteric modulators have be...

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Bibliografski detalji
Izdano u:Chem Biol
Glavni autori: Marotta, Christopher B., Lester, Henry A., Dougherty, Dennis A.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547686/
https://ncbi.nlm.nih.gov/pubmed/26211363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.06.018
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