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A dual effect of PNU-120596 on α7 nicotinic acetylcholine receptor-channel complexes
PNU-120596 (1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea), a Type-II positive allosteric modulator of α7 nicotinic acetylcholine receptors inhibits α7 desensitization and robustly prolongs openings of α7 channels. However, these effects may render α7 channels more accessible to pos...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2013
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3839061/ https://ncbi.nlm.nih.gov/pubmed/24036349 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2013.08.027 |
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