Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer

During chronic inflammation, neutrophil-secreted hypochlorous acid can damage nearby cells inducing the genomic accumulation of 5-chlorocytosine (5ClC), a known inflammation biomarker. Although 5ClC has been shown to promote epigenetic changes, it has been unknown heretofore if 5ClC directly perpetr...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Fedeles, Bogdan I., Freudenthal, Bret D., Yau, Emily, Singh, Vipender, Chang, Shiou-chi, Li, Deyu, Delaney, James C., Wilson, Samuel H., Essigmann, John M.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547254/
https://ncbi.nlm.nih.gov/pubmed/26243878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1507709112
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