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Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication
To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly. The essential mechanistic role of Cdc6 ATP hydrolysis in this reaction is still incompletely understood. Here, w...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4547096/ https://ncbi.nlm.nih.gov/pubmed/26305410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05795 |
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