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Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1
To start DNA replication, the Origin Recognition Complex (ORC) and Cdc6 load a Mcm2-7 double hexamer onto DNA. Without ATP hydrolysis, ORC-Cdc6 recruits one Cdt1-bound Mcm2-7 hexamer, forming an ORC-Cdc6-Cdt1-Mcm2-7 (OCCM) helicase loading intermediate. Here we report a 3.9Å structure of the OCCM on...
Tallennettuna:
| Julkaisussa: | Nat Struct Mol Biol |
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| Päätekijät: | , , , , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2017
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5503505/ https://ncbi.nlm.nih.gov/pubmed/28191893 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3372 |
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