Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1

To start DNA replication, the Origin Recognition Complex (ORC) and Cdc6 load a Mcm2-7 double hexamer onto DNA. Without ATP hydrolysis, ORC-Cdc6 recruits one Cdt1-bound Mcm2-7 hexamer, forming an ORC-Cdc6-Cdt1-Mcm2-7 (OCCM) helicase loading intermediate. Here we report a 3.9Å structure of the OCCM on...

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Publicado no:Nat Struct Mol Biol
Main Authors: Yuan, Zuanning, Riera, Alberto, Bai, Lin, Sun, Jingchuan, Nandi, Saikat, Spanos, Christos, Chen, Zhuo Angel, Barbon, Marta, Rappsilber, Juri, Stillman, Bruce, Speck, Christian, Li, Huilin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503505/
https://ncbi.nlm.nih.gov/pubmed/28191893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3372
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