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Cdc6-induced Conformational Changes in ORC Bound To Origin DNA Revealed by Cryo-Electron Microscopy

The eukaryotic origin recognition complex (ORC) interacts with and remodels origins of DNA replication prior to initiation in S phase. Here we report single particle cryo-EM-derived structure of the supra-molecular assembly comprising of S. cerevisiae ORC, the replication initiation factor Cdc6 and...

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Main Authors: Sun, Jingchuan, Kawakami, Hironori, Zech, Juergen, Speck, Christian, Stillman, Bruce, Li, Huilin
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3299985/
https://ncbi.nlm.nih.gov/pubmed/22405012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.01.011
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