Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6

DNA replication origins serve as sites of replicative helicase loading. In all eukaryotes, the six-subunit origin recognition complex (Orc1-6; ORC) recognizes the replication origin. During late M-phase of the cell-cycle, Cdc6 binds to ORC and the ORC–Cdc6 complex loads in a multistep reaction and,...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yuan, Zuanning, Schneider, Sarah, Dodd, Thomas, Riera, Alberto, Bai, Lin, Yan, Chunli, Magdalou, Indiana, Ivanov, Ivaylo, Stillman, Bruce, Li, Huilin, Speck, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2020
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395460/
https://ncbi.nlm.nih.gov/pubmed/32669428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006231117
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