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Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6
DNA replication origins serve as sites of replicative helicase loading. In all eukaryotes, the six-subunit origin recognition complex (Orc1-6; ORC) recognizes the replication origin. During late M-phase of the cell-cycle, Cdc6 binds to ORC and the ORC–Cdc6 complex loads in a multistep reaction and,...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7395460/ https://ncbi.nlm.nih.gov/pubmed/32669428 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006231117 |
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