Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA

In eukaryotes, the Cdt1-bound replicative helicase core MCM2-7 is loaded onto DNA by the ORC-Cdc6 ATPase to form a pre-Replicative Complex (pre-RC) with a MCM2-7 double-hexamer encircling DNA. Using purified components in the presence of ATPγS, we have captured in vitro an intermediate in pre-RC ass...

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Hlavní autoři: Sun, Jingchuan, Evrin, Cecile, Samel, Stefan, Fernández-Cid, Alejandra, Riera, Alberto, Kawakami, Hironori, Stillman, Bruce, Speck, Christian, Li, Huilin
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3735830/
https://ncbi.nlm.nih.gov/pubmed/23851460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2629
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