The ORC/Cdc6/MCM2-7 complex facilitates MCM2-7 dimerization during prereplicative complex formation

The replicative mini-chromosome-maintenance 2–7 (MCM2-7) helicase is loaded in Saccharomyces cerevisiae and other eukaryotes as a head-to-head double-hexamer around origin DNA. At first, ORC/Cdc6 recruits with the help of Cdt1 a single MCM2-7 hexamer to form an ‘initial’ ORC/Cdc6/Cdt1/MCM2-7 complex...

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Detalhes bibliográficos
Main Authors: Evrin, Cecile, Fernández-Cid, Alejandra, Riera, Alberto, Zech, Juergen, Clarke, Pippa, Herrera, M. Carmen, Tognetti, Silvia, Lurz, Rudi, Speck, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936773/
https://ncbi.nlm.nih.gov/pubmed/24234446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1148
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