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A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication
During pre-replication complex (pre-RC) formation, origin recognition complex (ORC), Cdc6, and Cdt1 cooperatively load the 6-subunit mini chromosome maintenance (MCM2-7) complex onto DNA. Loading of MCM2-7 is a prerequisite for DNA licensing that restricts DNA replication to once per cell cycle. Dur...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787165/ https://ncbi.nlm.nih.gov/pubmed/19910535 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911500106 |
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