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Incorporation into the prereplicative complex activates the Mcm2–7 helicase for Cdc7–Dbf4 phosphorylation

The essential S-phase kinase Cdc7–Dbf4 acts at eukaryotic origins of replication to trigger a cascade of protein associations that activate the Mcm2–7 replicative helicase. Also known as Dbf4-dependent kinase (DDK), this kinase preferentially targets chromatin-associated Mcm2–7 complexes that are as...

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Hlavní autoři: Francis, Laura I., Randell, John C.W., Takara, Thomas J., Uchima, Lilen, Bell, Stephen P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2658526/
https://ncbi.nlm.nih.gov/pubmed/19270162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1759609
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