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Incorporation into the prereplicative complex activates the Mcm2–7 helicase for Cdc7–Dbf4 phosphorylation
The essential S-phase kinase Cdc7–Dbf4 acts at eukaryotic origins of replication to trigger a cascade of protein associations that activate the Mcm2–7 replicative helicase. Also known as Dbf4-dependent kinase (DDK), this kinase preferentially targets chromatin-associated Mcm2–7 complexes that are as...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2658526/ https://ncbi.nlm.nih.gov/pubmed/19270162 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1759609 |
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