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Dbf4-Cdc7 Phosphorylation of Mcm2 Is Required for Cell Growth
The Dbf4-Cdc7 kinase (DDK) is required for the activation of the origins of replication, and DDK phosphorylates Mcm2 in vitro. We find that budding yeast Cdc7 alone exists in solution as a weakly active multimer. Dbf4 forms a likely heterodimer with Cdc7, and this species phosphorylates Mcm2 with su...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2781428/ https://ncbi.nlm.nih.gov/pubmed/19692334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.039123 |
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