The CREB/CRTC2 Pathway Modulates Autoimmune Disease by Promoting Th17 Differentiation

Following their activation in response to inflammatory signals, innate immune cells secrete T cell polarizing cytokines that promote the differentiation of naïve CD4 T cells into T helper (Th) cell subsets. Amongst these, Th17 cells play a prominent role in the development of a number of autoimmune...

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Pubblicato in:Nat Commun
Autori principali: Hernandez, Jeniffer B., Chang, Christina, LeBlanc, Mathias, Grimm, David, Le Lay, John, Kaestner, Klaus H., Zheng, Ye, Montminy, Marc
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545657/
https://ncbi.nlm.nih.gov/pubmed/26031354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8216
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