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Disomy 21 in spermatozoa and the paternal origin of trisomy 21 Down syndrome

BACKGROUND: Trisomy 21 Down syndrome is the most common genetic cause for congenital malformations and intellectual disability. It is well known that in the outstanding majority of cases the extra chromosome 21 originates from the mother but only in less than 10 % from the father. The mechanism unde...

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Publicado en:Mol Cytogenet
Autores principales: Iwarsson, Erik, Kvist, Ulrik, Hultén, Maj A.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545544/
https://ncbi.nlm.nih.gov/pubmed/26300975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13039-015-0155-2
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