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Disomy 21 in spermatozoa and the paternal origin of trisomy 21 Down syndrome

BACKGROUND: Trisomy 21 Down syndrome is the most common genetic cause for congenital malformations and intellectual disability. It is well known that in the outstanding majority of cases the extra chromosome 21 originates from the mother but only in less than 10 % from the father. The mechanism unde...

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Detalhes bibliográficos
Publicado no:Mol Cytogenet
Main Authors: Iwarsson, Erik, Kvist, Ulrik, Hultén, Maj A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545544/
https://ncbi.nlm.nih.gov/pubmed/26300975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13039-015-0155-2
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