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Disomy 21 in spermatozoa and the paternal origin of trisomy 21 Down syndrome

BACKGROUND: Trisomy 21 Down syndrome is the most common genetic cause for congenital malformations and intellectual disability. It is well known that in the outstanding majority of cases the extra chromosome 21 originates from the mother but only in less than 10 % from the father. The mechanism unde...

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Bibliografiske detaljer
Udgivet i:Mol Cytogenet
Main Authors: Iwarsson, Erik, Kvist, Ulrik, Hultén, Maj A.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545544/
https://ncbi.nlm.nih.gov/pubmed/26300975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13039-015-0155-2
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