Inhibition of Inflammation with Celastrol Fails to Improve Muscle Function in Dysferlin-deficient A/J Mice

The dysferlin-deficient A/J mouse strain represents a homologous model for limb-girdle muscular dystrophy 2B. We evaluated the disease phenotype in 10 month old A/J mice compared to two dysferlin-sufficient, C57BL/6 and A/JOlaHsd, mouse lines to determine which functional end-points are sufficiently...

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Pubblicato in:J Neurol Sci
Autori principali: Dillingham, Blythe C, Klimek, Margaret E Benny, Gernapudi, Ramkishore, Rayavarapu, Sree, Gallardo, Eduard, Van der Meulen, Jack H, Jordan, Sarah, Ampong, Beryl, Gordish-Dressman, Heather, Spurney, Christopher F, Nagaraju, Kanneboyina
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545396/
https://ncbi.nlm.nih.gov/pubmed/26119397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jns.2015.06.042
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