Characterization of Dysferlin Deficient SJL/J Mice to Assess Preclinical Drug Efficacy: Fasudil Exacerbates Muscle Disease Phenotype

The dysferlin deficient SJL/J mouse strain is commonly used to study dysferlin deficient myopathies. Therefore, we systematically evaluated behavior in relatively young (9–25 weeks) SJL/J mice and compared them to C57BL6 mice to determine which functional end points may be the most effective to use...

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Main Authors: Rayavarapu, Sree, Van der meulen, Jack H., Gordish-Dressman, Heather, Hoffman, Eric P., Nagaraju, Kanneboyina, Knoblach, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2010
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2945315/
https://ncbi.nlm.nih.gov/pubmed/20886045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012981
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