MBNL Sequestration by Toxic RNAs and RNA Mis-Processing in the Myotonic Dystrophy Brain

For some neurological disorders, disease is primarily RNA-mediated due to expression of non-coding microsatellite expansion RNAs (RNA(exp)). Toxicity is thought to result from enhanced binding of proteins to these expansions and depletion from their normal cellular targets. However, experimental evi...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Goodwin, Marianne, Mohan, Apoorva, Batra, Ranjan, Lee, Kuang-Yung, Charizanis, Konstantinos, Gómez, Francisco José Fernández, Eddarkaoui, Sabiha, Sergeant, Nicolas, Buée, Luc, Kimura, Takashi, Clark, H. Brent, Dalton, Joline, Takamura, Kenji, Weyn-Vanhentenryck, Sebastien, Zhang, Chaolin, Reid, Tammy, Ranum, Laura P.W., Day, John W., Swanson, Maurice S.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545389/
https://ncbi.nlm.nih.gov/pubmed/26257173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.029
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki