Loss of MBNL Leads to Disruption of Developmentally Regulated Alternative Polyadenylation in RNA-Mediated Disease

Inhibition of muscleblind-like (MBNL) activity due to sequestration by microsatellite expansion RNAs is a major pathogenic event in the RNA-mediated disease myotonic dystrophy (DM). Although MBNL1 and MBNL2 bind to nascent transcripts to regulate alternative splicing during muscle and brain developm...

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Publicado no:Mol Cell
Main Authors: Batra, Ranjan, Charizanis, Konstantinos, Manchanda, Mini, Mohan, Apoorva, Li, Moyi, Finn, Dustin J., Goodwin, Marianne, Zhang, Chaolin, Sobczak, Krzysztof, Thornton, Charles A., Swanson, Maurice S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4224598/
https://ncbi.nlm.nih.gov/pubmed/25263597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.08.027
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