MBNL Sequestration by Toxic RNAs and RNA Mis-Processing in the Myotonic Dystrophy Brain

For some neurological disorders, disease is primarily RNA-mediated due to expression of non-coding microsatellite expansion RNAs (RNA(exp)). Toxicity is thought to result from enhanced binding of proteins to these expansions and depletion from their normal cellular targets. However, experimental evi...

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Publicado no:Cell Rep
Main Authors: Goodwin, Marianne, Mohan, Apoorva, Batra, Ranjan, Lee, Kuang-Yung, Charizanis, Konstantinos, Gómez, Francisco José Fernández, Eddarkaoui, Sabiha, Sergeant, Nicolas, Buée, Luc, Kimura, Takashi, Clark, H. Brent, Dalton, Joline, Takamura, Kenji, Weyn-Vanhentenryck, Sebastien, Zhang, Chaolin, Reid, Tammy, Ranum, Laura P.W., Day, John W., Swanson, Maurice S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4545389/
https://ncbi.nlm.nih.gov/pubmed/26257173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.07.029
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