Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

Amyotrophic lateral sclerosis is a rapidly progressing neurodegenerative disease associated with protein misfolding and aggregation. Most cases are characterized by TDP-43 positive inclusions, while a minority of familial ALS cases are instead FUS and SOD1 positive respectively. Cells can generate i...

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Publicat a:Sci Rep
Autors principals: Farrawell, Natalie E., Lambert-Smith, Isabella A., Warraich, Sadaf T., Blair, Ian P., Saunders, Darren N., Hatters, Danny M., Yerbury, Justin J.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4544019/
https://ncbi.nlm.nih.gov/pubmed/26293199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep13416
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