Ubiquitin Homeostasis Is Disrupted in TDP-43 and FUS Cell Models of ALS

A major feature of amyotrophic lateral sclerosis (ALS) pathology is the accumulation of ubiquitin (Ub) into intracellular inclusions. This sequestration of Ub may reduce the availability of free Ub, disrupting Ub homeostasis and ultimately compromising cellular function and survival. We previously r...

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Bibliografiska uppgifter
I publikationen:iScience
Huvudupphovsmän: Farrawell, Natalie E., McAlary, Luke, Lum, Jeremy S., Chisholm, Christen G., Warraich, Sadaf T., Blair, Ian P., Vine, Kara L., Saunders, Darren N., Yerbury, Justin J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7644588/
https://ncbi.nlm.nih.gov/pubmed/33196025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101700
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