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Addition of exogenous SOD1 aggregates causes TDP-43 mislocalisation and aggregation

ALS is characterised by a focal onset of motor neuron loss, followed by contiguous outward spreading of pathology throughout the nervous system, resulting in paralysis and death generally within a few years after diagnosis. The aberrant release and uptake of toxic proteins including SOD1 and TDP-43...

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書目詳細資料
發表在:Cell Stress Chaperones
Main Authors: Zeineddine, Rafaa, Farrawell, Natalie E., Lambert-Smith, Isabella A., Yerbury, Justin J.
格式: Artigo
語言:Inglês
出版: Springer Netherlands 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655364/
https://ncbi.nlm.nih.gov/pubmed/28560609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-017-0804-y
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