The Fanconi Anemia DNA Repair Pathway Is Regulated by an Interaction between Ubiquitin and the E2-like Fold Domain of FANCL

The Fanconi Anemia (FA) DNA repair pathway is essential for the recognition and repair of DNA interstrand crosslinks (ICL). Inefficient repair of these ICL can lead to leukemia and bone marrow failure. A critical step in the pathway is the monoubiquitination of FANCD2 by the RING E3 ligase FANCL. FA...

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Foilsithe in:J Biol Chem
Main Authors: Miles, Jennifer A., Frost, Mark G., Carroll, Eilis, Rowe, Michelle L., Howard, Mark J., Sidhu, Ateesh, Chaugule, Viduth K., Alpi, Arno F., Walden, Helen
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2015
Ábhair:
Protein Structure and Folding
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543658/
https://ncbi.nlm.nih.gov/pubmed/26149689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.675835
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