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The structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex

The Fanconi Anemia pathway is activated in response to DNA damage, leading to monoubiquitination of the substrates FANCI and FANCD2 by the Fanconi Anemia core complex. Here we report the crystal structure of FANCL, the catalytic subunit of the Fanconi Anemia core complex at 3.2 Å. The structure reve...

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Main Authors: Cole, Ambrose R., Lewis, Laurence P.C., Walden, Helen
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929457/
https://ncbi.nlm.nih.gov/pubmed/20154706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1759
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