Development of taste masked caffeine citrate formulations utilizing hot melt extrusion technology and in vitro-in vivo evaluations

The objective of this study was to develop caffeine citrate orally disintegrating tablet (ODT) formulations utilizing hot-melt extrusion technology and evaluate the ability of the formulation composition to mask the unpleasant bitter taste of the drug using in vitro and in vivo methods. Ethylcellulo...

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Detalhes bibliográficos
Publicado no:Int J Pharm
Main Authors: Pimparade, Manjeet. B., Morott, Joseph T., Park, Jun-Bom, Kulkarni, Vijay I., Majumdar, Soumyajit, Murthy, S. N., Lian, Zhuoyang, Pinto, Elanor, Bi, Vivian, Durig, Thomas, Murthy, Reena, Shivakumar, H.N, Vanaja, K., Kumar, C. P, Repka, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543393/
https://ncbi.nlm.nih.gov/pubmed/25888797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2015.04.030
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