Bypass of a 5′,8-cyclopurine-2′-deoxynucleoside by DNA polymerase β during DNA replication and base excision repair leads to nucleotide misinsertions and DNA strand breaks

5′,8-cyclopurine-2′-deoxynucleosides including 5′,8-cyclo-dA (cdA) and 5′,8-cyclo-dG (cdG) are induced by hydroxyl radicals resulting from oxidative stress such as ionizing radiation. 5′,8-cyclopurine-2′-deoxynucleoside lesions are repaired by nucleotide excision repair with low efficiency, thereby...

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Veröffentlicht in:DNA Repair (Amst)
Hauptverfasser: Jiang, Zhongliang, Xu, Meng, Lai, Yanhao, Laverde, Eduardo E., Terzidis, Michael A., Masi, Annalisa, Chatgilialoglu, Chryssostomos, Liu, Yuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543387/
https://ncbi.nlm.nih.gov/pubmed/26123757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2015.06.004
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