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An ameliorative protocol for the quantification of purine 5′,8-cyclo-2′-deoxynucleosides in oxidized DNA

5′,8-Cyclo-2′-deoxyadenosine (cdA) and 5′,8-cyclo-2′-deoxyguanosine (cdG) are lesions resulting from hydroxyl radical (HO(·)) attack on the 5′H of the nucleoside sugar moiety and exist in both 5′R and 5′S diastereomeric forms. Increased levels of cdA and cdG are linked to Nucleotide Excision Repair...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Terzidis, Michael A., Chatgilialoglu, Chryssostomos
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517065/
https://ncbi.nlm.nih.gov/pubmed/26284235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2015.00047
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