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An ameliorative protocol for the quantification of purine 5′,8-cyclo-2′-deoxynucleosides in oxidized DNA

5′,8-Cyclo-2′-deoxyadenosine (cdA) and 5′,8-cyclo-2′-deoxyguanosine (cdG) are lesions resulting from hydroxyl radical (HO(·)) attack on the 5′H of the nucleoside sugar moiety and exist in both 5′R and 5′S diastereomeric forms. Increased levels of cdA and cdG are linked to Nucleotide Excision Repair...

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Pubblicato in:Front Chem
Autori principali: Terzidis, Michael A., Chatgilialoglu, Chryssostomos
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4517065/
https://ncbi.nlm.nih.gov/pubmed/26284235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2015.00047
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