Apolipoprotein CIII promotes Ca(2+)-dependent β cell death in type 1 diabetes

In type 1 diabetes (T1D), there is a specific destruction of the insulin secreting pancreatic β cell. Although the exact molecular mechanisms underlying β cell destruction are not known, sera from T1D patients have been shown to promote Ca(2+)-induced apoptosis. We now demonstrate that apolipoprotei...

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Hlavní autoři: Juntti-Berggren, Lisa, Refai, Essam, Appelskog, Ioulia, Andersson, Mats, Imreh, Gabriela, Dekki, Nancy, Uhles, Sabine, Yu, Lina, Griffiths, William J., Zaitsev, Sergei, Leibiger, Ingo, Yang, Shao-Nian, Olivecrona, Gunilla, Jörnvall, Hans, Berggren, Per-Olof
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC454169/
https://ncbi.nlm.nih.gov/pubmed/15210953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403551101
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