Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes

Insulin resistance and β-cell failure are the major defects in type 2 diabetes mellitus. However, the molecular mechanisms linking these two defects remain unknown. Elevated levels of apolipoprotein CIII (apoCIII) are associated not only with insulin resistance but also with cardiovascular disorders...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Åvall, Karin, Ali, Yusuf, Leibiger, Ingo B., Leibiger, Barbara, Moede, Tilo, Paschen, Meike, Dicker, Andrea, Daré, Elisabetta, Köhler, Martin, Ilegems, Erwin, Abdulreda, Midhat H., Graham, Mark, Crooke, Rosanne M., Tay, Vanessa S. Y., Refai, Essam, Nilsson, Stefan K., Jacob, Stefan, Selander, Lars, Berggren, Per-Olof, Juntti-Berggren, Lisa
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4443338/
https://ncbi.nlm.nih.gov/pubmed/25941406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423849112
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