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Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases

The minichromosome maintenance (MCM) 2-7 helicase complex functions to initiate and elongate replication forks. Cell cycle checkpoint signaling pathways regulate DNA replication to maintain genomic stability. We describe four lines of evidence that ATM/ATR-dependent (ataxia-telangiectasia-mutated/AT...

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Detalhes bibliográficos
Main Authors: Cortez, David, Glick, Gloria, Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC454167/
https://ncbi.nlm.nih.gov/pubmed/15210935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403410101
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