Artemis Is a Phosphorylation Target of ATM and ATR and Is Involved in the G(2)/M DNA Damage Checkpoint Response

Mutations in Artemis in both humans and mice result in severe combined immunodeficiency due to a defect in V(D)J recombination. In addition, Artemis mutants are radiosensitive and chromosomally unstable, which has been attributed to a defect in nonhomologous end joining (NHEJ). We show here, however...

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Detalhes bibliográficos
Main Authors: Zhang, Xiaoshan, Succi, Janice, Feng, Zhaohui, Prithivirajsingh, Sheela, Story, Michael D., Legerski, Randy J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC517881/
https://ncbi.nlm.nih.gov/pubmed/15456891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.20.9207-9220.2004
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