Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence

In Caenorhabditis elegans, ablation of germline stem cells (GSCs) extends lifespan, but also increases fat accumulation and alters lipid metabolism, raising the intriguing question of how these effects might be related. Here, we show that a lack of GSCs results in a broad transcriptional reprogrammi...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Steinbaugh, Michael J, Narasimhan, Sri Devi, Robida-Stubbs, Stacey, Moronetti Mazzeo, Lorenza E, Dreyfuss, Jonathan M, Hourihan, John M, Raghavan, Prashant, Operaña, Theresa N, Esmaillie, Reza, Blackwell, T Keith
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4541496/
https://ncbi.nlm.nih.gov/pubmed/26196144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07836
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