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TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO
The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR modulates lifespan will identify mechanisms of fundamental importance in aging, and TOR functions. Here we show that when TOR...
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| Główni autorzy: | , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
2012
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3348514/ https://ncbi.nlm.nih.gov/pubmed/22560223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.04.007 |
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