TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR modulates lifespan will identify mechanisms of fundamental importance in aging, and TOR functions. Here we show that when TOR...

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Detalhes bibliográficos
Main Authors: Robida-Stubbs, Stacey, Glover-Cutter, Kira, Lamming, Dudley W., Mizunuma, Masaki, Narasimhan, Sri Devi, Neumann-Haefelin, Elke, Sabatini, David M., Blackwell, T. Keith
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348514/
https://ncbi.nlm.nih.gov/pubmed/22560223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.04.007
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