TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

The TOR kinase, which is present in the functionally distinct complexes TORC1 and TORC2, is essential for growth but associated with disease and aging. Elucidation of how TOR modulates lifespan will identify mechanisms of fundamental importance in aging, and TOR functions. Here we show that when TOR...

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Bibliografische gegevens
Hoofdauteurs: Robida-Stubbs, Stacey, Glover-Cutter, Kira, Lamming, Dudley W., Mizunuma, Masaki, Narasimhan, Sri Devi, Neumann-Haefelin, Elke, Sabatini, David M., Blackwell, T. Keith
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348514/
https://ncbi.nlm.nih.gov/pubmed/22560223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.04.007
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