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Scaffold protein SLP-76 primes PLCγ1 for activation by ITK mediated phosphorylation
Activation of the phospholipase, PLCγ1, is critical for proper T cell signaling following antigen receptor engagement. In T cells, the Tec family kinase, ITK, phosphorylates PLCγ1 at tyrosine 783 (Y783) leading to activation of phospholipase function and subsequent production of the second messenger...
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| Pubblicato in: | J Mol Biol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4540666/ https://ncbi.nlm.nih.gov/pubmed/25916191 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2015.04.012 |
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