HTLV-1 Tax Stimulates Ubiquitin E3 Ligase, Ring Finger Protein 8, to Assemble Lysine 63-Linked Polyubiquitin Chains for TAK1 and IKK Activation

Human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, impacts a multitude of cellular processes, including I-κB kinase (IKK)/NF-κB signaling, DNA damage repair, and mitosis. These activities of Tax have been implicated in the development of adult T-cell leukemia (ATL) in HTLV-...

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Udgivet i:PLoS Pathog
Main Authors: Ho, Yik-Khuan, Zhi, Huijun, Bowlin, Tara, Dorjbal, Batsukh, Philip, Subha, Zahoor, Muhammad Atif, Shih, Hsiu-Ming, Semmes, Oliver John, Schaefer, Brian, Glover, J. N. Mark, Giam, Chou-Zen
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540474/
https://ncbi.nlm.nih.gov/pubmed/26285145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005102
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