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HTLV-1 Tax-Induced Rapid Senescence Is Driven by the Transcriptional Activity of NF-κB and Depends on Chronically Activated IKKα and p65/RelA

The HTLV-1 oncoprotein Tax is a potent activator of classical and alternative NF-κB pathways and is thought to promote cell proliferation and transformation via NF-κB activation. We showed recently that hyperactivation of NF-κB by Tax triggers a cellular senescence response (H. Zhi et al., PLoS Path...

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Bibliografski detalji
Glavni autori: Ho, Yik-Khuan, Zhi, Huijun, DeBiaso, Dominic, Philip, Subha, Shih, Hsiu-Ming, Giam, Chou-Zen
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416137/
https://ncbi.nlm.nih.gov/pubmed/22740410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00158-12
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