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NF-κB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti-Sense Protein HBZ

Activation of I-κB kinases (IKKs) and NF-κB by the human T lymphotropic virus type 1 (HTLV-1) trans-activator/oncoprotein, Tax, is thought to promote cell proliferation and transformation. Paradoxically, expression of Tax in most cells leads to drastic up-regulation of cyclin-dependent kinase inhibi...

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Detaylı Bibliyografya
Asıl Yazarlar: Zhi, Huijun, Yang, Liangpeng, Kuo, Yu-Liang, Ho, Yik-Khuan, Shih, Hsiu-Ming, Giam, Chou-Zen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3084201/
https://ncbi.nlm.nih.gov/pubmed/21552325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002025
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