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Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence

The human T-lymphotropic virus type 1 (HTLV-1) Tax binds the anaphase promoting complex (APC) and activates it ahead of schedule. Here, we show that APC activation by Tax induces rapid senescence (tax-IRS) independently of p53 and pRB. In response to tax, cyclin A, cyclin B1, securin, and Skp2 becom...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kuo, Yu-Liang, Giam, Chou-Zen
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2006
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1440834/
https://ncbi.nlm.nih.gov/pubmed/16601696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601054
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