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Activation of the anaphase promoting complex by HTLV-1 tax leads to senescence
The human T-lymphotropic virus type 1 (HTLV-1) Tax binds the anaphase promoting complex (APC) and activates it ahead of schedule. Here, we show that APC activation by Tax induces rapid senescence (tax-IRS) independently of p53 and pRB. In response to tax, cyclin A, cyclin B1, securin, and Skp2 becom...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1440834/ https://ncbi.nlm.nih.gov/pubmed/16601696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601054 |
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