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Regulation of human T-lymphotropic virus type I latency and reactivation by HBZ and Rex.

Human T lymphotropic virus type I (HTLV-I) infection is largely latent in infected persons. How HTLV-1 establishes latency and reactivates is unclear. Here we show that most HTLV-1-infected HeLa cells become senescent. By contrast, when NF-κB activity is blocked, senescence is averted, and infected...

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Hlavní autoři: Subha Philip, Muhammad Atif Zahoor, Huijun Zhi, Yik-Khuan Ho, Chou-Zen Giam
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2014-04-01
Edice:PLoS Pathogens
On-line přístup:http://europepmc.org/articles/PMC3974842?pdf=render
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