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NF-κB Inhibition Facilitates the Establishment of Cell Lines That Chronically Produce Human T-Lymphotropic Virus Type 1 Viral Particles

Most human T-lymphotropic virus type 1 (HTLV-1)-infected HeLa and SupT1 cells cease proliferation and become senescent immediately after infection by HTLV-1 or transduction of the HTLV-1 tax gene. The cellular senescence response triggered by Tax is caused by hyperactivated NF-κB and mediated by cyc...

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Bibliografiske detaljer
Main Authors: Zahoor, Muhammad Atif, Philip, Subha, Zhi, Huijun, Giam, Chou-Zen
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957949/
https://ncbi.nlm.nih.gov/pubmed/24403591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02961-13
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