Tylosin polyketide synthase module 3: stereospecificity, stereoselectivity and steady-state kinetic analysis of β-processing domains via diffusible, synthetic substrates

Polyketide synthase (PKS) β-processing domains are responsible for much of the stereochemical complexity of polyketide natural products. Although the importance of β-processing domains has been well noted and significantly explored, key stereochemical details pertaining to cryptic stereochemistry an...

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Bibliographic Details
Published in:Chem Sci
Main Authors: Fiers, William D., Dodge, Greg J., Li, Yang, Smith, Janet L., Fecik, Robert A., Aldrich, Courtney C.
Format: Artigo
Language:Inglês
Published: Royal Society of Chemistry 2015
Subjects:
Chemistry
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540058/
https://ncbi.nlm.nih.gov/pubmed/26366283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01505g
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