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Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor

Overexpression of epidermal growth factor receptor (EGFR) is one of the frequent mechanisms implicated in cancer progression, and so is the overexpression of the enzyme phospholipase D (PLD) and its reaction product, phosphatidic acid (PA). However, an understanding of how these signaling molecules...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Hatton, Nathaniel, Lintz, Erin, Mahankali, Madhu, Henkels, Karen M., Gomez-Cambronero, Julian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539377/
https://ncbi.nlm.nih.gov/pubmed/26124282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00286-15
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