In Vitro and In Vivo Activity of Multi-Target Inhibitors Against Trypanosoma brucei

We tested a series of amidine and related compounds against Trypanosoma brucei. The most active compound was a biphenyldiamidine which had an EC(50) of 7.7 nM against bloodstream form parasites. There was little toxicity against two human cell lines with CC(50) > 100 μM. There was also good in vi...

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Vydáno v:ACS Infect Dis
Hlavní autoři: Yang, Gyongseon, Zhu, Wei, Wang, Yang, Huang, Guozhong, Byun, Sooyoung, Choi, Gahee, Li, Kai, Huang, Zhuoli, Docampo, Roberto, Oldfield, Eric, No, Joo Hwan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539249/
https://ncbi.nlm.nih.gov/pubmed/26295062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00068
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